Honeysuckle is relatively easy to care for, but may suffer from aphids, powdery mildew and spreading. Neem oil or a hard water mist can be used to combat aphids. Powdery mildew thrives in moist environments, so keep your plant well ventilated. Certain species can be invasive, so frequent pruning is necessary to keep it under control. Selecting the appropriate species for your area and following good plant care practices will reduce issues and ensure a healthy plant.